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Hypoxia may arise under physiological conditions, such as high-altitude exposure, or from pathological states including anemia, cardiovascular disease, chronic obstructive pulmonary disease (COPD), neurodegenerative diseases, and chronic kidney disease ( Conventional treatments for hypoxia, including oxygen therapy and intravenous oxygen carriers, can increase blood oxygen content but often fail to address underlying issues in microvascular perfusion

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10.1038/ki.2008.618 167 MarshallJ